翻訳と辞書 Words near each other ・ Rechthuis (Bellingwolde) ・ Rechtmehring ・ Rechtnia ・ Rechtop in de wind ・ Rechts der Isar Hospital ・ Reception Tower Utlandshörn ・ Reception Yard railway station ・ Receptionism ・ Receptionist ・ Receptive aphasia ・ Receptive field ・ Receptive Services Association of America ・ Receptivity ・ Receptor ・ Receptor (biochemistry) ・ Receptor activated solely by a synthetic ligand ・ Receptor activity-modifying protein ・ Receptor antagonist ・ Receptor editing ・ Receptor modulator ・ Receptor potential ・ Receptor protein serine/threonine kinase ・ Receptor theory ・ Receptor tyrosine kinase ・ Receptor tyrosine kinase-like orphan receptor ・ Receptor tyrosine phosphatase ・ Receptor-mediated endocytosis ・ Receptorome ・ Receptor–ligand kinetics ・ Recess Dictionary Lists mini英和辞書 mini和英辞書 Webster 1913 Latin-English FOLDOC Wikipedia English ウィキペディア

翻訳と辞書　辞書検索 [ 開発暫定版 ] スポンサード リンク Receptor activated solely by a synthetic ligand ： ウィキペディア英語版 Receptor activated solely by a synthetic ligand A receptor activated solely by a synthetic ligand (RASSL) or Designer Receptor Exclusively Activated by Designer Drugs (DREADD), permits spatial and temporal control of G protein signaling ''in vivo''. These systems utilize G protein-coupled receptors (GPCR) engineered to respond exclusively to synthetic small molecules ligands, like clozapine N-oxide (CNO), and not to their natural ligand(s). RASSL's represent a GPCR-based chemogenetic tool. ==Mechanism== RASSLs and DREADDs are a family of designer G-protein-coupled receptors (GPCRs) built specifically to allow for precise spatiotemporal control of GPCR signaling ''in vivo''. These engineered GPCRs, called RASSLs (receptors activated solely by synthetic ligands), are unresponsive to endogenous ligands but can be activated by nanomolar concentrations of pharmacologically inert, drug-like small molecules. Currently, RASSLs exist for the three major GPCR signaling pathways (Gs, Gi, Gq). A major cause for success of RASSL resources has been open exchange of DNA constructs, and RASSL related resources. 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「Receptor activated solely by a synthetic ligand」の詳細全文を読む スポンサード リンク 翻訳と辞書 : 翻訳のためのインターネットリソース Copyright(C) kotoba.ne.jp 1997-2016. All Rights Reserved.